- Lambda Light Chain (B-Cell Marker) Antibody
- MyBioSource.com
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- MBS4380045
- 0.02 mg (With BSA & Azide at 0.2mg/ml)
- Human. Others not known
- Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin
- Mouse
- ~22.5kDa
- immunoglobulin lambda locus
- IGLV, IGL@, IGLC6
- Unconjugated
- N10/2
- Lambda Light Chain
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
- Monoclonal
- IgG1 kappa
Specifications/Features
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant